Outcome after treatment for sebaceous carcinoma: A multicenter study

Area of Science:

• Oncology
• Dermatopathology
• Surgical Oncology

Background:

• Sebaceous carcinoma (SC) is a rare malignant neoplasm with limited long-term outcome data.
• Understanding SC behavior is crucial for effective patient management.

Purpose of the Study:

• To evaluate the long-term outcomes of patients undergoing surgical resection for sebaceous carcinoma.
• To identify prognostic factors associated with recurrence and metastasis.

Main Methods:

• A retrospective analysis of 100 patients with 103 SCs treated at four tertiary centers.
• Cumulative incidence curves were used to assess recurrence rates.
• Follow-up data were collected to determine rates of locoregional and distant metastases.

Main Results:

• The median age of patients was 72 years, with a median follow-up of 52 months.
• Local recurrence occurred in 16.5% of cases, with higher rates for (peri)ocular SCs and positive resection margins.
• Metastases were infrequent, with 8.7% developing lymph node metastases during follow-up.

Conclusions:

• Sebaceous carcinoma is a locally aggressive tumor.
• Positive resection margins and (peri)ocular location are significant risk factors for local recurrence.
• Distant or locoregional metastases are uncommon in SC patients.