Related Experiment Video
Updated: Oct 7, 2025
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
16.1K
Laponite-Based Nanomaterials for Drug Delivery
Gita Kiaee1, Nikolaos Dimitrakakis1, Shabnam Sharifzadeh2
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.
Advanced Healthcare Materials
|January 6, 2022
Summary
Laponite nanoparticles offer tunable pH-responsive drug delivery. Their properties allow for controlled release of therapeutics, enhancing drug delivery system efficacy.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Laponite is a synthetic clay nanoparticle with a disk-like structure, high ionic content, and large surface area.
- These properties facilitate the loading and release of biomolecules, making it suitable for drug delivery applications.
- Laponite's characteristics allow for the creation of pH-responsive drug delivery systems.
Purpose of the Study:
- To review the design principles for efficient therapeutic delivery using Laponite-based systems.
- To explore the role of Laponite's physicochemical properties in drug encapsulation and release.
- To highlight the potential of Laponite-polymer composites in advanced drug delivery platforms.
Main Methods:
- Review of existing literature on Laponite nanoparticles in drug delivery.
- Analysis of Laponite's structural and chemical properties relevant to drug interactions.
- Examination of Laponite-polymer composites and their therapeutic applications.
Main Results:
- Laponite's ionic nature and surface area are key for biomolecule intercalation and dissolution.
- Tunable pH-responsive drug release can be achieved by exploiting Laponite's properties.
- Cation exchangeability and coagulation capacity influence drug loading and release kinetics.
Conclusions:
- Laponite nanoparticles provide a versatile platform for designing controlled and sustained drug release systems.
- Optimizing Laponite-polymer interactions and drug moieties is crucial for therapeutic efficacy.
- This review provides insights into leveraging Laponite for advanced drug delivery solutions.
Related Concept Videos
01:27Bioavailability Enhancement: Drug Permeability Enhancement
4
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
4
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.1K