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Updated: Oct 7, 2025

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
Published on: May 12, 2015
The Herc1 gene in neurobiology
Robert Lalonde1, Catherine Strazielle2
1University of Rouen, Dept Psychology, 76821 Mont-Saint-Aignan, France; Laboratory of Stress, Immunity, Pathogens (EA7300), University of Lorraine Medical School, Vandœuvre-les-Nancy, France.
Abstract:
The function of the HERC1 gene has mainly been delineated by studying Herc1tbl (tambaleante) mutant mice, characterized by losses in cerebellar Purkinje cells, a lower number of synaptic vesicles in the hippocampus, and anomalies in climbing fiber projections from the inferior olive as well as alpha-motoneuron projections to the skeletal muscle. The salient behavioral phenotypes include cerebellar ataxia, a loss in motor coordination, muscle weakness, and spatial deficits. Similar neuropathological and behavioral profiles have been described in childhood-onset subjects with HERC1 variants, including cerebellar ataxia and hypotonia.
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