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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Dexamethasone for Management of Cytokine Release Syndrome Associated With Talquetamab in Patients With Relapsed/Refractory Multiple Myeloma.

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Integrating Recent Evidence and Expert Perspectives Into the Management of Multiple Myeloma: Consensus Recommendations From the 2025 Bridging the Gaps Conference.

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Measuring Equitable Care Delivery: Insights From the Health Equity Report Card (HERC) Pilot in Academic Cancer Centers.

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Updated: Oct 7, 2025

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NCCN Guidelines® Insights: Multiple Myeloma, Version 3.2022.

Natalie S Callander1, Muhamed Baljevic2, Kehinde Adekola3

  • 11University of Wisconsin Carbone Cancer Center.

Journal of the National Comprehensive Cancer Network : JNCCN
|January 6, 2022
PubMed
Summary
This summary is machine-generated.

The National Comprehensive Cancer Network (NCCN) Guidelines for Multiple Myeloma offer updated recommendations for diagnosing and treating multiple myeloma. These insights focus on key changes in the 2022 guidelines for patient care.

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Area of Science:

  • Hematology
  • Oncology
  • Clinical Practice Guidelines

Background:

  • Multiple myeloma is a cancer of plasma cells.
  • Accurate diagnosis and treatment are crucial for patient outcomes.
  • Regular guideline updates ensure evidence-based care.

Purpose of the Study:

  • To summarize key updates in the 2022 NCCN Guidelines for Multiple Myeloma.
  • To highlight changes in diagnosis, treatment, and supportive care.
  • To inform clinicians about the latest recommendations for plasma cell neoplasms.

Main Methods:

  • Review of the 2022 NCCN Guidelines for Multiple Myeloma.
  • Identification of significant modifications and additions to previous versions.
  • Focus on treatment strategies and patient management.

Main Results:

  • The 2022 guidelines include updated recommendations for the initial workup of multiple myeloma.
  • Key changes address treatment options and supportive care protocols.
  • The guidelines cover various aspects of managing plasma cell neoplasms.

Conclusions:

  • The updated NCCN Guidelines provide essential information for managing multiple myeloma.
  • Clinicians should be aware of the 2022 revisions for optimal patient care.
  • These guidelines support evidence-based decision-making in multiple myeloma treatment.