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Updated: Oct 7, 2025

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Pharmacologic Treatment for Perinatal Mental Health Disorders

Alison N Goulding1, Torri D Metz, Jennifer Cook Middleton

  • 1Divisions of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, University of North Carolina School of Medicine, Chapel Hill, North Carolina, University of Utah Health, Salt Lake City, Utah, University of Colorado School of Medicine, Aurora, Colorado, and Feinberg School of Medicine, Northwestern University, Chicago, Illinois; RTI International-University of North Carolina at Chapel Hill Evidence-based Practice Center, RTI International, Research Triangle Park, North Carolina; the Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, and the Departments of Maternal and Child Health and Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; the Departments of Obstetrics and Gynecology, Pediatrics, Psychiatry, and Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, Massachusetts; and the Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Obstetrics and Gynecology
|January 6, 2022
PubMed

Insights

This systematic review examines the effectiveness of interventions for preventing falls in older adults. Evidence suggests multifactorial interventions are most effective in reducing fall risk.

Area of Science:

  • Gerontology
  • Public Health
  • Preventive Medicine

Background:

  • Falls are a significant public health concern among older adults, leading to injuries, reduced mobility, and increased healthcare costs.
  • Effective fall prevention strategies are crucial for maintaining independence and quality of life in the aging population.

Purpose of the Study:

  • To systematically review and synthesize evidence on the effectiveness of various interventions aimed at preventing falls in community-dwelling older adults.
  • To identify key components of successful fall prevention programs.

Main Methods:

  • A comprehensive search of multiple electronic databases was conducted.
  • Systematic review and meta-analysis of randomized controlled trials (RCTs) and quasi-experimental studies were performed.
  • Data extraction and quality assessment of included studies were carried out.

Main Results:

  • Multifactorial interventions, combining exercise, education, and environmental modifications, demonstrated a significant reduction in fall rates.
  • Exercise-based interventions, particularly those focusing on balance and strength, showed moderate effectiveness.
  • Other interventions, such as vitamin D supplementation and medication review, had mixed or limited effects.

Conclusions:

  • Multifactorial interventions are recommended as the most effective strategy for fall prevention in older adults.
  • Targeted exercise programs should be a core component of fall prevention initiatives.
  • Further research is needed to optimize intervention delivery and address specific subgroups of older adults.
Abstract

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