Biomedical applications of tannic acid

Area of Science:

• Biomedical Research
• Materials Science
• Pharmacology

Background:

• Tannic acid (TA) is a naturally occurring antioxidant polyphenol with a history of traditional uses.
• Its utility stems from hydroxyl groups enabling hydrogen bonding with biomolecules.
• TA is sourced from oak tree galls and has historical applications in tanning, inks, wines, and medicine.

Purpose of the Study:

• To explore the diverse biomedical and biomaterials applications of tannic acid.
• To highlight TA's potential in pharmaceuticals, drug delivery, and advanced materials.

Main Methods:

• Review of existing literature on tannic acid's biochemical properties and applications.
• Analysis of TA's demonstrated effects, including antioxidant, anti-inflammatory, antimicrobial, and anticancer activities.
• Examination of TA's role in biomaterials as a crosslinking agent and in drug delivery systems.

Main Results:

• TA exhibits antioxidant, anti-inflammatory, antibiotic, antiviral, and antifungal properties.
• It can induce apoptosis in cancer cells and protect against neurodegenerative diseases.
• TA serves as a natural crosslinking agent for hydrogels and polymers, enhancing material properties and bioactivity.
• TA is effective in treating gastrointestinal disorders and severe burns.

Conclusions:

• Tannic acid is a versatile molecule with broad potential in pharmaceutical and biomedical applications.
• Its use in biomaterials enhances material properties and confers therapeutic benefits.
• TA is a promising agent for developing novel drug delivery strategies and medical treatments.