Computerized cognitive training in people with depression: a protocol for a systematic review and meta-analysis

Area of Science:

• Neuroscience
• Psychiatry
• Cognitive Psychology

Background:

• Depression frequently co-occurs with cognitive impairment.
• Computerized cognitive training (CCT) is a recognized intervention for cognitive enhancement in various clinical groups.
• The effectiveness of CCT specifically for individuals with depression remains uncertain.

Purpose of the Study:

• To systematically review and meta-analyze the efficacy of CCT in adults with depression.
• To explore variations in CCT efficacy based on study design factors and population characteristics.
• To assess the impact of CCT on cognitive, mood, psychiatric, psychosocial, and daily functioning outcomes.

Main Methods:

• A comprehensive search of MEDLINE, EMBASE, and PsycINFO databases was conducted up to July 13, 2021.
• Included were randomized controlled trials comparing CCT with control conditions in adults with depression (major depressive disorder or other diagnoses with >=50% depressive criteria).
• Primary outcome was change in overall cognitive performance; multivariate analyses examined effect sizes, modifiers, and outcome correlations. Risk of bias was assessed using Cochrane Risk of Bias tool v2.

Main Results:

• This section is to be filled upon study completion.

Conclusions:

• This will be the first systematic review and meta-analysis focusing on narrowly defined CCT in depressed populations.
• The study aims to determine CCT's efficacy for cognition and other outcomes, and to identify factors influencing its effectiveness across diverse patient groups.