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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same authorSame journal

Agreement in the classification of keratoconus severity: a comparative study based on anterior corneal surface topographic parameters.

Contact lens & anterior eye : the journal of the British Contact Lens Association·2026
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Dose-Dependent Effects of Atropine on Accommodative and Binocular Visual Function for Myopia Control in Children: A Systematic Review and Meta-Analysis.

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Validation and comparison of two commercial OCT systems for in vitro measurement of soft contact lens thickness.

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One-Year Impact of Scleral Lens Wear on Corneal Morphology in Keratoconus with and Without Intracorneal Ring Segment.

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Related Experiment Video

Updated: Oct 7, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

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Keratoconus: An updated review.

Jacinto Santodomingo-Rubido1, Gonzalo Carracedo2, Asaki Suzaki3

  • 1Global R&D, Menicon Co. Ltd, Nagoya, Japan.

Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association
|January 7, 2022
PubMed
Summary
This summary is machine-generated.

Keratoconus is a progressive eye condition causing corneal thinning and steepening, leading to vision loss. Early detection and varied treatments, from glasses to surgery and corneal cross-linking, are crucial for managing this disease.

Keywords:
AetiologyClassificationDetectionEpidemiologyHistopathologyManagement

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Area of Science:

  • Ophthalmology
  • Corneal Diseases

Background:

  • Keratoconus is a bilateral, asymmetric corneal disease causing progressive thinning and steepening.
  • Traditionally considered noninflammatory, recent evidence links keratoconus to ocular inflammation.
  • It typically develops in the second to fourth decades of life, affecting all ethnicities.

Purpose of the Study:

  • To provide an updated review of keratoconus.
  • To cover definition, epidemiology, histopathology, etiology, pathogenesis, clinical features, detection, classification, and management.

Main Methods:

  • Review of current literature on keratoconus.
  • Analysis of epidemiological data, histopathological findings, and risk factors.
  • Evaluation of diagnostic tools and treatment strategies.

Main Results:

  • Keratoconus prevalence varies (0.2-4,790/100,000), with higher incidence in younger adults and specific ethnicities.
  • Key risk factors include family history, eye rubbing, eczema, asthma, and allergies.
  • Early detection challenges necessitate combined use of corneal topography, pachymetry, and aberration data.

Conclusions:

  • Keratoconus management depends on severity, ranging from spectacles and contact lenses to surgical interventions like corneal cross-linking.
  • Accurate classification systems aid in tailoring treatment strategies.
  • Continued research is vital for understanding and managing keratoconus progression.