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Updated: Oct 7, 2025

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
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Acute limb ischaemia due to vasospasm: a rare presentation

Raed Al Yacoub1, Jaymin Patel2, Neha Solanky2

  • 1Department of Medicine, University of Florida, Gainesville, Florida, USA raed.alyacoub@medicine.ufl.edu.

BMJ Case Reports
|January 7, 2022
PubMed

A 30-year-old woman with active intravenous drug use presented with pain, blue discolouration, paresthesia and lack of grip strength of left hand for 1 week. Physical examination revealed blue discolouration, decreased sensation and cold to touch in the left hand. She had no palpable radial pulse. She admitted Heroin use only but the urine drug screen was also positive for amphetamine. CT angiogram of the left upper extremity was concerning for acute ischaemia due to arterial occlusion. The initial plan was for amputation. However, to salvage the limb with thrombolysis, an interventional radiology angiogram was performed. The angiogram demonstrated diffuse arterial spasm and response to nitroglycerin. She was treated with nitroglycerin drip and transitioned to a calcium channel blocker. She did improve significantly. To ensure no embolic sequelae, the patient was discharged with a month of oral anticoagulation.

Keywords:
drug therapy related to surgeryinterventional radiologymedical managementorthopaedic and trauma surgeryvascular surgery

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