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Could the systemic immune-inflammation index be a predictor to estimate cerebrovascular events in hypertensive

Cihan Aydin1, Şeref Alpsoy1, Aydin Akyüz1

  • 1Department of Cardiology, Faculty of Medicine, Namik Kemal University, Tekirdağ.

Blood Pressure Monitoring
|January 7, 2022
PubMed

Insights

The systemic immune-inflammation index (SII) can predict stroke in hypertensive patients. High SII levels are linked to an increased risk of cerebrovascular events in this population.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Neurology

Background:

  • Hypertension is a major risk factor for cardiovascular and cerebrovascular events.
  • Inflammatory processes play a key role in hypertension pathogenesis and organ damage.
  • Novel inflammatory markers are needed to predict hypertension-related complications.

Purpose of the Study:

  • To investigate the predictive value of the systemic immune-inflammation index (SII) for cerebrovascular events in hypertensive patients.
  • To assess the relationship between SII and stroke risk in individuals with hypertension.

Main Methods:

  • Retrospective analysis of ambulatory blood pressure monitoring data from 379 hypertensive patients.
  • Calculation of SII (platelet × neutrophil/lymphocyte ratio) from complete blood count.
  • Comparison of SII levels between patients with and without a history of stroke.

Main Results:

  • The systemic immune-inflammation index (SII) demonstrated high sensitivity (85.7%) and specificity (84.8%) in predicting stroke.
  • Receiver operating characteristic curve analysis indicated an area under the curve of 0.898 for SII.
  • Multivariate logistic regression revealed that age and SII were significantly associated with an increased stroke risk.

Conclusions:

  • The systemic immune-inflammation index (SII) is a valuable and accessible inflammatory marker for predicting stroke in hypertensive patients.
  • Elevated SII levels are indicative of a higher risk of stroke among individuals with hypertension.
Abstract

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