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Visual Evoked Potentials in Neuromyelitis Optica Spectrum Disorders.
Otto Jesus Hernandez Fustes1, Cláudia S K Kay1, Paulo José Lorenzoni1
1Neurology Service, Clinics Hospital Complex at Universidade Federal do Paraná, Curitiba, Brazil.
Visual evoked potentials (VEPs) reveal increased P100 latency in neuromyelitis optica spectrum disorders (NMOSDs), indicating optical pathway involvement. This non-invasive test aids in diagnosing NMOSD.
Area of Science:
- Neurophysiology
- Ophthalmology
- Neurology
Background:
- Neuromyelitis optica spectrum disorders (NMOSDs) are rare, antibody-mediated central nervous system diseases targeting the spinal cord and optic nerves.
- Visual evoked potentials (VEPs) are established diagnostic tools for multiple sclerosis, but their utility in NMOSD is less explored.
Observation:
- This study prospectively evaluated VEP responses in 13 patients diagnosed with NMOSD.
- VEPs were recorded according to International Federation of Clinical Neurophysiology standards.
Findings:
- A significant increase in P100 latency was observed in 20 of 24 evaluated eyes, without amplitude changes.
- No VEP response was obtained in 6 eyes.
Implications:
- VEP assessment demonstrates significant optical pathway involvement in NMOSD patients.
- VEP is a valuable, non-invasive, and cost-effective neurophysiological tool for NMOSD diagnosis.
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