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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

70
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

Tissue Transplantation

562
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

543
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
543
Blood Transfusion01:15

Blood Transfusion

867
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Targeting Vascular TRPV4 Activity Prevents Lung Transplant Ischemia-Reperfusion Injury and Rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
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Fate-mapping infiltrating monocytes following experimental myocardial infarction revealsdifferentiation trajectories in the infarcted heart.

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Donor heart injury caused by liver needle biopsy during multi-organ procurement surgery: A case report.

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Spatial transcriptomics reveals differences in bronchus-associated lymphoid tissue composition in stable and rejecting human lung allografts.

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Myeloid-avid mammalian target of rapamycin-inhibiting nanobiologic attenuates allograft fibrosis after lung transplantation.

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Related Experiment Video

Updated: Oct 7, 2025

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

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Advanced considerations in organ donors.

Hailey M Shepherd1, Jason M Gauthier1, Varun Puri1

  • 1Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.

Journal of Thoracic Disease
|January 7, 2022
PubMed
Summary
This summary is machine-generated.

Increasing lung transplantation requires expanding the donor pool. This review explores strategies for better donor selection, management, and procurement to maximize available lung allografts for patients needing transplants.

Keywords:
Lung transplantorgan donor

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Last Updated: Oct 7, 2025

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Area of Science:

  • Medicine
  • Transplantation Surgery
  • Organ Donation

Background:

  • Lung transplantation demand outpaces suitable allograft availability.
  • Limited donor supply and low utilization rates restrict lung transplant volumes.
  • Disparities exist in the adoption of donor pool expansion strategies among transplant centers.

Purpose of the Study:

  • To review methods for enhancing donor selection and expanding the lung donor pool.
  • To examine current practices and barriers in lung allograft availability.
  • To identify strategies for maximizing lung transplantation potential.

Main Methods:

  • Review of existing literature on donor assessment, management, and procurement.
  • Discussion of extended criteria donors, including high-risk groups.
  • Analysis of technological advancements (e.g., computed tomography) and logistical improvements (e.g., local procurement teams).

Main Results:

  • Extended criteria donors, such as those from drug overdose cases, can be utilized.
  • Advanced donor assessment and management protocols improve lung suitability.
  • Addressing barriers like organ procurement organization (OPO) practices and patient beliefs is crucial.

Conclusions:

  • Optimizing donor evaluation, management, and accessibility is key to increasing lung allograft availability.
  • Implementing standardized protocols and utilizing advanced techniques can expand the donor pool.
  • Overcoming logistical and societal barriers is essential for meeting the growing need for lung transplants.