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Related Concept Videos

Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

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Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
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A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
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Related Experiment Video

Updated: Oct 7, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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A strategy to determine off-axis dosimetric leaf gap using OSLD and EPID.

Janahiraman Divyalakshmi1, K Mohamathu Rafic1,2, Ebenezer Suman Babu1,2

  • 1Department of Radiation Oncology, Christian Medical College, Vellore, Tamil Nadu, India.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
|January 7, 2022
PubMed
Summary

Optically stimulated luminescence dosimeters (OSLD) and electronic portal imaging devices (EPID) accurately measure dosimetric leaf gap (DLG) on and off the central axis. The 2D DLG map from EPID data aids in precise treatment planning system commissioning.

Keywords:
dosimetric leaf gapelectronic portal imaging deviceoptically stimulated luminescence dosimeterrounded leaf-end transmission

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Dosimetry

Background:

  • Accurate measurement of the dosimetric leaf gap (DLG) is crucial for radiotherapy precision.
  • Traditional methods for DLG measurement can be complex and time-consuming.

Purpose of the Study:

  • To assess the dosimetric feasibility of using optically stimulated luminescence dosimeters (OSLD) and electronic portal imaging devices (EPID) for DLG measurements.
  • To compare OSLD and EPID-based DLG measurements with ionization chamber dosimetry (ICD).

Main Methods:

  • Utilized a Clinac 2100C/D linear accelerator with a Millennium-120 multileaf collimator (MLC).
  • Measured DLG at central axis (CAX) and off-axis (OAX) positions using OSLD (DLGOSLD) and validated with ICD (DLGICD).
  • Generated a 2D DLG map (2D DLGEPID) from portal images using custom software with correction factors.

Main Results:

  • DLGOSLD and DLGICD showed similar variations at CAX and OAX positions.
  • DLGEPID values agreed with DLGOSLD and DLGICD when using aperture-specific corrections.
  • The 2D DLGEPID map revealed varying DLG patterns for each leaf pair across the field.

Conclusions:

  • OSLDs are effective and validated dosimeters for DLG measurements, showing agreement with ionization chamber dosimetry.
  • The 2D DLGEPID map offers a novel approach for modeling leaf-end transmission and commissioning treatment planning systems.