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Regulation of Mitochondrial Function by the Actin Cytoskeleton

María Illescas1, Ana Peñas1, Joaquín Arenas1,2

  • 1Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.

Frontiers in Cell and Developmental Biology
|January 7, 2022
PubMed

Insights

The actin cytoskeleton and actin-binding proteins regulate mitochondrial functions, including trafficking and metabolism. Gelsolin

Area of Science:

  • Cell Biology
  • Mitochondrial Biology
  • Biochemistry

Background:

  • The actin cytoskeleton's role in mitochondrial function is emerging but poorly understood.
  • Actin-binding proteins (ABPs), like Gelsolin, are implicated in mitochondrial OXPHOS disorders via undefined mechanisms.

Purpose of the Study:

  • To review experimental evidence on the roles of the actin cytoskeleton and ABPs in mitochondrial functions.
  • To highlight Gelsolin's specific involvement in mitochondrial disorders.

Main Methods:

  • Literature review of experimental studies.
  • Focus on actin cytoskeleton and ABP interactions with mitochondria.

Main Results:

  • Actin cytoskeleton and ABPs are crucial for mitochondrial trafficking, dynamics, biogenesis, metabolism, and apoptosis.
  • Gelsolin plays a significant role in the pathophysiology of mitochondrial disorders.

Conclusions:

  • The interplay between the actin cytoskeleton, ABPs, and mitochondrial membranes is vital for cellular homeostasis.
  • This interaction presents a promising area for future research and therapeutic strategies in mitochondrial diseases.
Keywords:
OXPHOS systemactin cytoskeletongelsolinmitochondriamitochondrial disease

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