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Active rosette forming T-lymphocytes in diabetes mellitus
Experimental and Clinical Endocrinology
|August 1, 1987
Summary
Active rosette forming T lymphocytes (ARTL) decrease in new insulin-dependent diabetes cases. ARTL levels normalize over time, suggesting insulin influences these T cells, while non-insulin-dependent diabetics show normal ARTL counts.
Area of Science:
- Immunology
- Endocrinology
- T lymphocyte subpopulations
Background:
- Active rosette forming T lymphocytes (ARTL) are a T cell subpopulation with high affinity for sheep erythrocytes.
- ARTL are hypothesized to reflect cellular immune status and possess suppressor activity.
Purpose of the Study:
- To investigate the levels of ARTL in different types of diabetes mellitus.
- To explore the relationship between ARTL, disease onset, and glycemic control (HbA1c).
Main Methods:
- ARTL were quantified using the Wybran method.
- Study included insulin-dependent diabetics (IDD), non-insulin-dependent diabetics (NIDD) with varying HbA1c levels, and healthy controls.
Main Results:
- A significant decrease in ARTL was observed in IDD at disease onset.
- ARTL levels in IDD normalized by the third month post-manifestation.
- Both groups of NIDD exhibited normal ARTL levels, irrespective of HbA1c.
Conclusions:
- Insulin may influence ARTL levels.
- ARTL dynamics differ between IDD and NIDD.
- ARTL could serve as a biomarker for immune status in diabetes.