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Cochlear and vestibular involvement in children with IgA vasculitis
Abdulkadir Bucak1, Ayşegül Bükülmez2, Selçuk Kuzu3
1Otorhinolaryngology Department, Otorhinolaryngology Clinic, Afyonkarahisar Health Sciences University Medical Faculty, 03300, Afyonkarahisar, Turkey.
European Journal of Pediatrics
|January 7, 2022
Summary
IgA vasculitis is linked to childhood hearing loss and vestibular dysfunction. This study reveals significant sensorineural hearing loss and impaired vestibular function in affected children.
Area of Science:
- Pediatrics
- Otolaryngology
- Rheumatology
Background:
- IgA vasculitis is a systemic autoimmune disease with unknown etiology, affecting multiple organs.
- Previous literature lacks studies on the cochlear and vestibular implications of IgA vasculitis in children.
Purpose of the Study:
- To evaluate cochlear and vestibular function in pediatric patients with IgA vasculitis.
- To investigate the association between IgA vasculitis and auditory and balance system impairments.
Main Methods:
- Utilized audiometry, distortion product otoacoustic emissions, and cervical vestibular evoked myogenic potential (cVEMP) tests.
- Compared findings in 40 children with IgA vasculitis against 40 age- and sex-matched healthy controls.
Main Results:
- Children with IgA vasculitis showed statistically significant sensorineural hearing loss at 250 Hz (median 4.7 dB) and 8000 Hz (average 6.4 dB).
- Vestibular dysfunction was indicated by a significant increase in cVEMP p1-n1 latency (0.9 ms) and a decrease in amplitude (median 5.6 mV) in the IgA vasculitis group.
Conclusions:
- This study is the first to demonstrate a potential association between IgA vasculitis and hearing loss in children.
- Findings suggest IgA vasculitis may also be linked to vestibular dysfunction in pediatric patients, possibly due to autoimmune mechanisms.
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