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Distribution of alpha-1-antitrypsin and haptoglobin phenotypes in bladder cancer patients
H G Benkmann1, H P Hanssen, R Ovenbeck
1Institute of Human Genetics, University of Hamburg, FRG.
Human Heredity
|January 1, 1987
Abstract:
Frequencies of the alpha 1-antitrypsin (Pi) alleles and haptoglobin phenotypes have been determined in a series of 264 North-German patients with bladder cancer. Compared to a healthy control population, we found a statistically significant decrease of Hp 2-2 phenotype in the patient series. A significant increase of the serum Pi Z allele, as previously shown for patient groups with certain other tumours, could also be confirmed for bladder cancer. Furthermore, a distinct association between a lowered M 3 allele and bladder carcinoma was observed.