Related Experiment Video

Updated: Oct 7, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.8K

Vitamin K: A novel cancer chemosensitizer

Sameena Gul1,2, Muhammad Faisal Maqbool2, Amara Maryam2

  • 1School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Biotechnology and Applied Biochemistry
|January 7, 2022
PubMed

Insights

Vitamin K analogs combined with chemotherapy offer a safe and effective strategy to overcome cancer drug resistance. This approach enhances treatment efficacy by promoting apoptosis and cell cycle arrest.

Area of Science:

  • Oncology
  • Pharmacology
  • Nutritional Science

Background:

  • Rising global cancer incidence necessitates improved treatment strategies.
  • Chemotherapy faces significant challenges due to inherent drug resistance.
  • Combination therapy is a promising approach to enhance anti-cancer effects.

Purpose of the Study:

  • To review the potential of vitamin K analogs as anticancer agents.
  • To explore the role of vitamin K in overcoming chemotherapy drug resistance.
  • To provide a scientific basis for developing vitamin K as a chemosensitizer.

Main Methods:

  • Review of published literature on vitamin K, chemotherapy, and drug resistance.
  • Analysis of mechanisms by which vitamin K analogs modulate tumor response.
  • Discussion of cellular targets and development strategies for vitamin K as chemosensitizers.

Main Results:

  • Vitamin K analogs (K1, K2, K3, K5) combined with chemotherapy show promise.
  • This combination therapy is safe, cost-effective, and improves chemotherapy outcomes.
  • Vitamin K enhances efficacy by promoting apoptosis, cell cycle arrest, and inhibiting P-glycoprotein.

Conclusions:

  • Vitamin K analogs can act as effective chemosensitizers.
  • Combination therapy with vitamin K offers a viable strategy to overcome drug resistance.
  • Further development of vitamin K subtypes could significantly improve cancer treatment efficacy.
Keywords:
apoptosis. cancer chemosensitizerscell cycle arrestcombination therapymultiple signaling pathwaysvitamin K

More Related Videos

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

6.1K
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism05:36

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism

Published on: February 23, 2024

610

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
286
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
50.5K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.3K