Related Experiment Video
Updated: Oct 7, 2025
10:08
Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy
Published on: October 24, 2017
9.3K
Stability and Deformation of Vesicles in a Cylindrical Flow
Dan Liu1, Zhihao Zhang1, Rong Wang1
1Department of Polymer Science and Engineering, State Key Laboratory of Coordination Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences, Key Laboratory of High Performance Polymer Material and Technology of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Langmuir : the ACS Journal of Surfaces and Colloids
|January 7, 2022
Summary
This study used dissipative particle dynamics to investigate polymer vesicle behavior in flow. Increased confinement and shear rate cause vesicle deformation or rupture, with implications for flow applications.
Area of Science:
- Polymer Science
- Soft Matter Physics
- Fluid Dynamics
Background:
- Polymer vesicles are crucial in various applications, but their behavior under flow conditions remains complex.
- Understanding vesicle stability, deformation, and rupture is essential for designing effective microfluidic and drug delivery systems.
Purpose of the Study:
- To investigate the stability, deformation, and rupture mechanisms of polymer vesicles confined in cylindrical channels under flow.
- To explore the influence of confinement degree and dimensionless shear rate on vesicle morphology and dynamics.
Main Methods:
- Dissipative particle dynamics (DPD) simulations were employed.
- Vesicle morphology, elongation (asphericity parameter), and rupture times were analyzed under varying confinement and shear rates.
Main Results:
- Vesicle morphology evolved from spherical to bullet-like shapes with increasing confinement.
- Higher shear rates and confinement led to increased vesicle deformation and rupture.
- Rupture time decreased non-linearly with increasing shear rate, influenced by confinement.
Conclusions:
- Both confinement and shear rate significantly impact polymer vesicle stability and rupture.
- The findings provide valuable insights for controlling vesicle behavior in flow environments.
- This research aids in guiding the application of polymer vesicles in microfluidic devices and other flow-related technologies.
Related Concept Videos
01:23Steady, Laminar Flow in Circular Tubes
501
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is...
501
01:28Navier–Stokes Equations
909
For incompressible Newtonian fluids, where density remains constant, stresses show a linear relationship with the deformation rate, defined by normal and shear stresses. Normal stresses depend on the pressure exerted on the fluid and the rate of deformation in specific directions, which determines how fluid flows under varying pressures. Shear stresses, on the other hand, act tangentially across fluid layers. They explain how adjacent fluid layers slide relative to one another, connecting...
909
01:18Newtonian Fluid: Problem Solving
480
Newtonian fluids exhibit a constant viscosity, meaning their shear stress and shear strain rate are directly proportional. This property ensures a predictable and stable response to applied forces, maintaining a linear relationship between force and flow. Examples include water, air, and light oils, consistently demonstrating this proportional behavior regardless of external conditions.
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
480
01:32Pinching-off of Coated Vesicles
3.4K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.4K
01:20Stokes' Law
1.8K
Viscous forces, like friction, are intermolecular forces that resist the relative motion of molecules over each other. When a solid body moves through a liquid, viscous forces drag it in the opposite direction. The force's magnitude depends on the solid's shape and size, as well as its speed and the liquid's coefficient of viscosity, density and temperature.
The expression for the force on a solid spherical object in a fluid is called Stokes' law. Stokes' law is valid only...
The expression for the force on a solid spherical object in a fluid is called Stokes' law. Stokes' law is valid only...
1.8K
01:07Laminar and Turbulent Flow
9.4K
Fluid dynamics is the study of fluids in motion. Velocity vectors are often used to illustrate fluid motion in applications like meteorology. For example, wind—the fluid motion of air in the atmosphere—can be represented by vectors indicating the speed and direction of the wind at any given point on a map. Another method for representing fluid motion is a streamline. A streamline represents the path of a small volume of fluid as it flows. When the flow pattern changes with time, the...
9.4K