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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
1,2-Dicarbofunctionalization of Trifluoromethyl Alkenes with Pyridinium Salts via a
Shu-Jie Chen1, Guo-Shu Chen1, Tao Deng2
1School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, P. R. China.
Abstract:
Although trifluoromethyl alkenes have great synthetic potential, their 1,2-difunctionalization has been a challenge. In this Letter, we disclose the first 1,2-dicarbofunctionalization of trifluoromethyl alkenes with pyridinium salts via a cascade process involving a base-promoted [3 + 2] cycloaddition followed by a visible-light-mediated Norrish-type-II fragmentation. This protocol allows for the formation of pyridines bearing a trifluoromethyl-substituted quaternary center in moderate to excellent yields under mild conditions.
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