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Association Between Pre-delivery Coagulation Indicators and Invasive Placenta Accreta Spectrum
Zhirong Guo1,2, Xueyan Han3, Huijing Zhang1,2
1Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Summary
Preoperative coagulation tests like PT, D-dimer, and FDP can predict the severity of invasive placenta accreta spectrum (PAS) and intraoperative blood loss. These indicators are crucial for managing PAS patients.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Surgical Outcomes
Background:
- Placenta accreta spectrum (PAS) is a severe obstetric complication.
- Accurate prediction of PAS severity and associated blood loss is critical for patient management.
Purpose of the Study:
- To investigate the association between preoperative coagulation indicators and the severity of invasive PAS.
- To analyze the correlation between these indicators and intraoperative blood loss.
Main Methods:
- Retrospective analysis of 95 invasive PAS patients (2018-2020).
- Evaluation of six preoperative coagulation indicators.
- Logistic and Poisson regression models used to assess associations with FIGO grade and blood loss.
Main Results:
- Higher Prothrombin Time (PT) and Fibrin Degradation Products (FDP) linked to increased risk of severe PAS (FIGO grade 3).
- Elevated D-dimer and FDP levels correlated with greater intraoperative blood loss.
Conclusions:
- Preoperative PT, D-dimer, and FDP are valuable indicators for predicting PAS severity and blood loss.
- Further research is needed to elucidate the mechanisms behind coagulation changes in PAS.
