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Correlation between vitamin D levels and bone metabolism in children with cow's milk allergy
1Department of Children's Health Care, 90405Guangdong Women and Children Hospital, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
Insights
Cow's milk protein allergy (CMPA) in infants is linked to lower vitamin D levels and altered bone metabolism markers. CMPA is identified as a risk factor for vitamin D deficiency in children.
Area of Science:
- Pediatric Gastroenterology
- Nutritional Biochemistry
- Pediatric Endocrinology
Background:
- Limited research exists on bone metabolism biochemical markers in children with cow's milk protein allergy (CMPA).
- Understanding these markers is crucial for managing potential long-term health implications.
Purpose of the Study:
- To compare vitamin D and bone metabolism markers between infants with CMPA and healthy controls.
- To investigate the relationship between these markers in infants with CMPA.
Main Methods:
- A cross-sectional study comparing 41 infants with CMPA to 50 healthy infants.
- Measurement of serum biomarkers including 25-hydroxyvitamin D (25(OH)D), bone-specific alkaline phosphatase (BALP), serum phosphorus, and serum calcitonin.
Main Results:
- Infants with CMPA had significantly lower serum 25(OH)D levels compared to controls.
- Reduced levels of BALP, serum phosphorus, and serum calcitonin were observed in the CMPA group.
- CMPA was identified as a risk factor for vitamin D deficiency.
Conclusions:
- Cow's milk protein allergy is associated with disruptions in bone metabolism.
- Children with CMPA exhibit lower vitamin D levels, highlighting CMPA as a risk factor for deficiency.
Objective:
Research is limited regarding biochemical markers of bone metabolism among children with cow's milk protein allergy (CMPA). We aimed to determine differences in vitamin D and bone metabolism markers between infants with CMPA and healthy infants and explore relationships between these in a cross-sectional study.
Methods:
In total, we included 41 children diagnosed with CMPA and under systematic medical and nutritional care at our center, and 50 healthy children as a control group. We reviewed demographic and clinical characteristics and measured serum biomarkers.
Results:
We found that serum 25-hydroxyvitamin D (25(OH)D) levels among infants in the CMPA group were significantly lower than those in the control group, and levels of bone-specific alkaline phosphatase (BALP), serum phosphorus, and serum calcitonin were reduced. Pearson correlation analysis showed that serum 25(OH)D concentrations in the CMPA group were negatively correlated with parathyroid hormone but not significantly correlated with calcitonin and BALP. Logistic regression showed that CMPA was a risk factor for vitamin D deficiency.
Conclusions:
Our study indicated that CMPA was associated with disturbances in bone metabolism. Levels of vitamin D in children with CMPA were lower than those in healthy children. CMPA was a risk factor for vitamin D deficiency.
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