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Updated: Oct 7, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Ester-directed orthogonal dual C-H activation and ortho aryl C-H alkenylation via distal weak coordination
Manickam Bakthadoss1, Tadiparthi Thirupathi Reddy1, Vishal Agarwal1
1Department of Chemistry, Pondicherry University, Pondicherry-605014, India. bhakthadoss@yahoo.com.
Abstract:
An unprecedented orthogonal cross-coupling between aromatic C(sp2) and aliphatic olefinic C(sp2) carbons of two same molecules via dual C-H bond activation in an intermolecular fashion has been developed using a distal ester-directing group. This new coupling reaction led to the synthesis of the highly functionalized 1,3-diaryl molecular architecture in very good yields and with high chemo- and regioselectivities. In addition, using ester as the distal directing group, ortho C-H olefination of α-methyl aryl acrylates and cinnamic esters with various alkenes has been achieved in very good yields and with a wide range of substrate scope.
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