[Management strategies for chronic rhinosinusitis with nasal polyps]

Area of Science:

• Otolaryngology
• Immunology

Background:

• Chronic rhinosinusitis (CRS) significantly affects patient quality of life.
• Symptoms include nasal obstruction, olfactory dysfunction, discharge, and facial pain.
• Nasal polyps (CRwNP) represent a severe subtype of CRS (CRsNP).

Purpose of the Study:

• To summarize current understanding and treatment of CRS.
• To highlight the role of emerging therapies.

Main Methods:

• Review of diagnostic standards including nasal endoscopy and CT scans.
• Discussion of established treatments: glucocorticoids, nasal rinsing, surgery.
• Inclusion of recently approved monoclonal antibody therapies.

Main Results:

• CRS diagnosis relies on clinical symptoms and imaging.
• Multiple treatment modalities exist, from conservative to surgical.
• Monoclonal antibodies represent a novel therapeutic avenue.

Conclusions:

• CRS significantly impacts quality of life and requires comprehensive management.
• Monoclonal antibodies offer a new treatment option for CRS patients in Germany since 2019.