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Related Concept Videos

Holter Monitor: 24-Hour Monitoring01:23

Holter Monitor: 24-Hour Monitoring

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Holter monitoring is a continuous electrocardiography (ECG) recording that tracks the heart's electrical activity over an extended period, generally 24 to 48 hours. This noninvasive diagnostic tool detects irregular heart rhythms that may not be captured during a standard ECG performed in a clinical setting.DeviceThe Holter monitor is a portable, small device connected to several electrodes on the patient's chest. These electrodes detect the heart's electrical signals and transmit them to the...
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Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
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Related Experiment Video

Updated: Oct 7, 2025

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Wearable Cortisol Aptasensor for Simple and Rapid Real-Time Monitoring.

Jai Eun An1, Kyung Ho Kim1, Seon Joo Park1

  • 1Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.

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|January 7, 2022
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Summary
This summary is machine-generated.

A new wearable biosensor offers simple, real-time monitoring of cortisol, a key stress hormone. This flexible device allows for rapid detection in sweat, aiding in stress management and mental health monitoring.

Keywords:
aptasensorbiosensorcortisolflexibleswappablewearable

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Rising global stress levels, exacerbated by events like the COVID-19 pandemic, highlight the need for effective stress hormone management.
  • Cortisol, a primary stress hormone, is linked to anxiety and depression, but current monitoring methods are complex and time-consuming.
  • There is a critical need for accessible, rapid, and user-friendly methods for real-time cortisol level assessment.

Purpose of the Study:

  • To develop a flexible and wearable aptasensor for simple and rapid real-time cortisol monitoring.
  • To create a biosensor platform capable of detecting cortisol with high sensitivity and selectivity.
  • To demonstrate the practical application of the wearable aptasensor for on-site and continuous monitoring of stress biomarkers.

Main Methods:

  • Fabrication of a sensing channel using electrospun polyacrylonitrile (PAN) nanofibers coated with carboxylated poly(3,4-ethylenedioxythiophene) (PEDOT).
  • Conjugation of cortisol aptamers onto the PEDOT-PAN nanofibers to create the specific sensing mechanism.
  • Integration of the aptasensor with a liquid-ion gated field-effect transistor (FET) on a polyester substrate for signal transduction.

Main Results:

  • The cortisol aptasensor achieved a low detection limit of 10 pM with a response time under 5 seconds.
  • Demonstrated high selectivity, accurately detecting cortisol even in the presence of interfering substances at 100-fold higher concentrations.
  • Successfully validated in real-time monitoring applications, including transfer to skin and detection of approximately 1 nM cortisol in human sweat within minutes.

Conclusions:

  • The developed flexible and wearable cortisol aptasensor provides a simple and rapid method for real-time stress hormone monitoring.
  • The liquid-ion gated FET-based biosensor platform shows significant potential for on-site biomarker detection.
  • This technology paves the way for broader applications in continuous health monitoring and the detection of various other biomarkers.