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Published on: May 6, 2014
Inflammation Resolution: Implications for Atherosclerosis
1Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt Institute for Infection, Immunology and Inflammation, Department of Molecular Physiology and Biophysics and Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN.
Abstract:
Resolution is an active and highly coordinated process that occurs in response to inflammation to limit tissue damage and promote repair. When the resolution program fails, inflammation persists. It is now understood that failed resolution is a major underlying cause of many chronic inflammatory diseases. Here, we will review the major failures of resolution in atherosclerosis, including the imbalance of proinflammatory to pro-resolving mediator production, impaired clearance of dead cells, and functional changes in immune cells that favor ongoing inflammation. In addition, we will briefly discuss new concepts that are emerging as possible regulators of resolution and highlight the translational significance for the field.
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