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Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

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Recurrent Low-Grade Gliomas: Does Reoperation Affect Neurocognitive Functioning?

Sam Ng^1,2, Anne-Laure Lemaitre^1,2, Sylvie Moritz-Gasser^1,2,3

¹Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.

|January 7, 2022

Summary

This summary is machine-generated.

Second surgeries for recurrent low-grade gliomas (RLGG) using awake monitoring are safe and effective. Most patients experienced stable or improved neurocognitive function, with a high return-to-work rate, supporting systematic reoperation consideration.

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Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Area of Science:

Neurosurgery
Neuro-oncology
Cognitive Neuroscience

Background:

Reoperations for recurrent low-grade gliomas (RLGG) aim to manage residual tumor and prevent malignant transformation.
Assessing neurocognitive outcomes after a second surgery for RLGG is crucial for patient quality of life.

Purpose of the Study:

To investigate the neurocognitive outcomes in patients with RLGG who underwent a second surgery with awake monitoring.

Main Methods:

Retrospective analysis of patients undergoing second awake surgery for RLGG.
Pre- and 3-month post-operative neuropsychological assessments using Z-scores.
Analysis of cognitive deficits, score variations, and extent of resection (EOR).

Main Results:

Sixty-two patients included; no permanent neurological deficits.
6.5% developed new cognitive deficits post-reoperation; 12.9% had pre-existing deficits.
94.2% returned to work; 91.9% achieved total/subtotal resection.

Conclusions:

Reoperation with awake monitoring is compatible with early neurocognitive recovery in RLGG patients.
Favorable outcomes suggest reoperation should be considered more systematically.
High rates of resection and return to work indicate the benefit of reoperation.