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Single-dose antibiotic therapy for urinary infections during pregnancy: A systematic review and meta-analysis of
Gabriel Schuch Schulz1, Felipe Schütz1, Felipe Valentim Jung Spielmann1
1Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFGRS), Porto Alegre, Brazil.
Background:
During pregnancy, urinary infections are an important cause of maternofetal morbidity and mortality and may lead to several complications.
Objective:
To verify whether the use of antibiotic therapy in a single dose when compared with multiple doses in lower tract urinary infections during pregnancy is effective to obtain microbiologic cure.
Search Strategy:
Online databases were searched. Keywords used were "single-drug dose", "antibiotic", "fosfomycin", "amoxicillin", "trimethoprim", "pregnancy", and "urinary tract infection".
Selection Criteria:
Studies were included if they were randomized controlled trials, the population was pregnant woman, microbiologic cure was attained, and one of the treatment groups received single-dose antibiotic therapy.
Data Collection And Analysis:
Preselected studies have been independently read by pairs, and data were extracted according to a predetermined sheet. The Cochrane tool was used for the risk of bias.
Main Results:
A total of 1063 women from nine studies were included. The primary outcome was the microbiologic cure attested by urine culture. When compared with the multiple-day use of antibiotics, the single-dose treatment has shown statistically similar results in reaching culture cure (odds ratio 1.02, 95% confidence interval 0.73-1.44).
Conclusion:
The current study has shown that the use of single-dose treatment for lower tract urinary infections during pregnancy can be recommended, especially using fosfomycin.
Systematic Review Registration:
This review has not been registered.
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