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Axillary Granular Parakeratosis.

Kayla J Riswold1, B Joel Tjarks1,2, Jana B Johnson1,3

  • 1University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

South Dakota Medicine : the Journal of the South Dakota State Medical Association
|January 7, 2022
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Summary
This summary is machine-generated.

A rare skin condition, axillary granular parakeratosis, presents as itchy, scaly patches. Microscopic findings confirmed this benign diagnosis, distinct from viral infections.

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Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Axillary granular parakeratosis is a rare, benign skin condition.
  • It is characterized by a defect in epidermal differentiation.
  • This condition is often underreported in clinical practice.

Observation:

  • An 85-year-old female presented with pruritic, scaly, hyperpigmented papules and plaques in the left axilla.
  • Initial concern for varicella zoster infection led to antiviral treatment.
  • A shave biopsy was performed for definitive diagnosis.

Findings:

  • Microscopic examination revealed compact hyperparakeratosis with keratohyalin granules.
  • Eosinophils were observed within the stratum corneum.
  • Epidermal changes included acanthosis and irregular hyperplasia of rete ridges, confirming axillary granular parakeratosis.

Implications:

  • Accurate diagnosis of axillary granular parakeratosis is crucial to distinguish it from other dermatoses.
  • Awareness of this condition aids clinicians in reassuring patients about its benign nature.
  • Appropriate identification facilitates correct treatment recommendations and patient management.