Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

66.9K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.9K
Pleiotropy01:33

Pleiotropy

41.4K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
41.4K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.7K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.7K
Incomplete Dominance01:43

Incomplete Dominance

26.3K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
26.3K
General Transcription Factors01:30

General Transcription Factors

5.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.8K
Human Genetics01:28

Human Genetics

793
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
793

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From winter flounder to multifunctional applications: A review of pleurocidin-like peptides via visualization and trend analysis.

Microbial pathogenesis·2026
Same author

SIRT2 mediates integrated stress response by deacetylating and stabilizing 4E-BP1 to suppress translation.

EMBO reports·2026
Same author

The impact of antidiabetic drugs on dementia risk: a Bayesian network meta-analysis.

Frontiers in endocrinology·2026
Same author

Inhibition of extracellular vesicle secretion by cannabidiol: A promising approach for oral squamous cell carcinoma therapy.

Biochemical pharmacology·2026
Same author

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers.

Annals of clinical and translational neurology·2026
Same author

A Self-Assembling Nanomodulator for Synergistic Therapy of Intracerebral Hemorrhage.

International journal of nanomedicine·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: Oct 7, 2025

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

21.2K

Limb development genes underlie variation in human fingerprint patterns.

Jinxi Li1, James D Glover2, Haiguo Zhang3

  • 1State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200438, PRC; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC.

Cell
|January 7, 2022
PubMed
Summary
This summary is machine-generated.

Genetic factors influence fingerprint patterns. Researchers found specific gene locations (loci) linked to fingerprint types and correlations, highlighting the role of limb development genes in shaping these unique human traits.

Keywords:
EVI1fingerprint patterngeneticsgenome-wide association studylimb developmenttrans-ethnic meta-analysis

More Related Videos

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
09:53

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo

Published on: May 20, 2011

17.8K
Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

2.4K

Related Experiment Videos

Last Updated: Oct 7, 2025

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

21.2K
Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
09:53

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo

Published on: May 20, 2011

17.8K
Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

2.4K

Area of Science:

  • Genetics
  • Developmental Biology
  • Human Variation

Background:

  • Fingerprint variation has long been recognized but poorly understood at a mechanistic level.
  • Previous research lacked comprehensive genetic insights into the determinants of fingerprint patterns.

Purpose of the Study:

  • To identify genetic loci associated with fingerprint types and patterns.
  • To investigate the role of specific genes, such as EVI1, in dermatoglyphic variation.
  • To explore the genetic correlation between fingerprint patterns and hand proportions.

Main Methods:

  • Genome-wide association studies (GWAS) were conducted in Han Chinese cohorts.
  • A trans-ethnic meta-analysis was performed to identify additional associated loci.
  • Gene expression analysis and mouse models were used to investigate the function of candidate genes.

Main Results:

  • 18 loci associated with fingerprint type were identified in Han Chinese cohorts.
  • A variant near the EVI1 gene was linked to altered regulatory activity and dermatoglyph patterning in mice.
  • Trans-ethnic meta-analysis identified 43 fingerprint-associated loci, enriched for limb development pathways.
  • Genetic correlations were found between fingerprint patterns and hand proportions.

Conclusions:

  • Limb development genes play a crucial role in determining fingerprint patterns.
  • The study provides a genetic basis for observed correlations in fingerprint patterns.
  • EVI1 is implicated in dermatoglyph patterning, with expression dynamics suggesting a role in limb and digit shaping.