Related Experiment Video
Updated: Oct 7, 2025

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
Published on: December 10, 2014
Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives
Tatiane Azevedo Rubio1, Bruno Rodrigues2, Larissa Morete Caieiro da Costa1
1Hypertension Clinic, Internal Medicine Department, Medical School of São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil.
Abstract:
Resistant hypertension (RHT) is associated with worse outcomes among patients, and sympathetic overactivity is a challenge in treating this clinical condition. Here, we evaluated the autonomic modulation (by linear and non-linear analyses), central blood pressure, and pulse wave velocity in controlled and uncontrolled RHT patients, as well as those in use of beta-blockers. We observed that uncontrolled RHT patients display, in addition to an increase in peripheral blood pressure, presented higher central blood pressure values concerning controlled RHT. Furthermore, despite the use of beta-blockers, both patients in the RHT + beta-blockers and uncontrolled RHT groups had negative changes in autonomic balance as compared with controlled RHT. These results reinforce the importance of autonomic nervous system interventions in managing arterial hypertension.
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Hypertension III: Clinical Manifestations and Diagnostic Studies
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
Hypertension II: Pathophysiology
Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's...

