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Related Experiment Video

Updated: Oct 7, 2025

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
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A fully implantable wireless bidirectional neuromodulation system for mice.

Jason P Wright1, Ibrahim T Mughrabi1, Jason Wong1

  • 1Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, United States.

Biosensors & Bioelectronics
|January 7, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a miniature, implantable neuromodulation system for mice, enabling advanced bioelectronic medicine research. This device allows wireless control of neurostimulation and bio-signal recording, advancing therapeutic discovery.

Keywords:
Biocompatible packagingImplantable devicesNeuromodulationPeripheral nerve stimulationWireless systems

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Area of Science:

  • Bioelectronic Medicine
  • Neuroscience
  • Biomedical Engineering

Background:

  • Developing effective bioelectronic medicine requires sophisticated neuromodulation systems.
  • Existing systems are often too large and power-hungry for use in mice, a common research model.
  • This limits the scope and feasibility of preclinical studies.

Purpose of the Study:

  • To present a fully-implantable, miniaturized neuromodulation system for mice.
  • To enable high-performance neurostimulation and bio-signal acquisition in a small animal model.
  • To facilitate the translation of bioelectronic therapeutics.

Main Methods:

  • Designed a compact (2.2 cm³, 2.8 g) implantable device with a bidirectional wireless interface.
  • Integrated high-performance neurostimulation and multi-channel bio-signal recording capabilities.
  • Utilized commercially available components and 3D-printed packaging for accessibility.

Main Results:

  • Demonstrated successful vagus nerve stimulation in 12 animals.
  • Achieved a functional neural interface capable of inducing acute bradycardia.
  • The system exhibited device lifetimes exceeding three weeks with wirelessly rechargeable batteries (up to 5 days per charge).

Conclusions:

  • The developed neuromodulation system overcomes size and power limitations for mouse studies.
  • It offers a versatile platform for advancing bioelectronic medicine research and therapeutic development.
  • The design promotes widespread adoption and accelerates discovery in the field.