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A bimodal BI-RADS-guided GoogLeNet-based CAD system for solid breast masses discrimination using transfer learning.

Zahra Assari1, Ali Mahloojifar1, Nasrin Ahmadinejad2

  • 1Department of Biomedical Engineering, Faculty of Electrical and Computer Engineering, Tarbiat Modares University, Tehran, Iran.

Computers in Biology and Medicine
|January 7, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a novel bimodal computer-aided diagnosis (CAD) system that combines mammography and ultrasound images for solid breast mass classification. The system significantly improves diagnostic accuracy for breast cancer detection.

Keywords:
Bimodal CAD systemDeep learningMammographySolid massTransfer learningUltrasound imaging

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence in Medicine
  • Oncology

Background:

  • Accurate diagnosis of solid breast masses is crucial for effective treatment planning.
  • Integrating information from multiple imaging modalities like mammography and ultrasound presents a diagnostic challenge for radiologists.
  • Existing computer-aided diagnosis (CAD) systems often analyze imaging data from a single modality, limiting diagnostic potential.

Purpose of the Study:

  • To develop and evaluate a novel bimodal CAD system for solid breast mass classification using both mammographic and sonographic images.
  • To enhance diagnostic performance by effectively combining complementary information from different imaging modalities.
  • To leverage deep learning techniques, specifically GoogLeNet, for improved accuracy in breast cancer detection.

Main Methods:

  • A bimodal GoogLeNet-based CAD system was developed, training distinct monomodal models first, followed by a bimodal model using high-level feature maps.
  • Image content representations were optimized to exploit BI-RADS descriptors for comprehensive analysis.
  • A two-step transfer learning strategy was employed using an ImageNet pre-trained GoogLeNet model and multiple datasets.

Main Results:

  • The bimodal model achieved high performance metrics: 90.91% sensitivity, 89.87% specificity, 90.32% F1-score, 80.78% Matthews Correlation Coefficient, 95.82% AUC, and 90.38% accuracy.
  • The proposed system demonstrated superior recognition results compared to monomodal approaches.
  • The integration of mammographic and sonographic data significantly enhanced the classification of solid breast masses.

Conclusions:

  • The novel bimodal CAD system effectively integrates information from mammography and ultrasound for solid breast mass classification.
  • The system shows significant potential to improve breast cancer diagnostic performance and assist radiologists.
  • This approach offers a promising direction for developing advanced AI tools in breast imaging analysis.