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Decrease in ultrasound Brain Tissue Pulsations as a potential surrogate marker of response to antidepressant.

Thomas Desmidt1, Paul-Armand Dujardin2, Bruno Brizard3

  • 1UMR 1253, IBrain, Université de Tours, Inserm, Tours, France; CHU de Tours, Tours, France.

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Successful antidepressant treatment reduced excessive Brain Tissue Pulsations (BTP) in major depressive episode (MDE) patients. This suggests therapy may lower brain damage risk and TPI can monitor treatment response.

Keywords:
Brain tissue pulsatilityCerebral auto-regulationDepressionNeuroimaging markerTissue pulsatility imagingTreatment resistant depression

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Previous studies linked excessive Brain Tissue Pulsations (BTP) to depression, suggesting a potential mechanism for brain damage.
  • It was unclear if antidepressant therapy could reverse these BTP changes.

Purpose of the Study:

  • To investigate longitudinal changes in BTP in patients with major depressive episode (MDE) during an 8-week escitalopram trial.
  • To compare BTP changes between responders and non-responders to antidepressant treatment.

Main Methods:

  • Prospective study of 52 individuals with MDE, treated with escitalopram.
  • Ultrasound Tissue Pulsatility Imaging (TPI) measured BTP at baseline and 8 weeks.
  • Participants were categorized into responders (n=28) and non-responders (n=20) based on MADRS score changes.

Main Results:

  • MaxBTP significantly decreased from baseline to week 8, but only in responders.
  • BTP reactivity during an orthostatic challenge normalized in responders by week 8.
  • No significant changes in BTP were observed in non-responders.

Conclusions:

  • Successful escitalopram treatment in MDE patients is associated with a reduction in BTP.
  • This suggests antidepressant therapy may mitigate the risk of depression-related brain damage.
  • TPI shows promise as a biomarker for monitoring antidepressant response and brain health.