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Related Experiment Video

Updated: Oct 7, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method.

William J Windsor¹, Vijaya Knight², Patricia A Merkel²

¹Colorado School of Public Health, Anschutz Medical Campus, Aurora, Colorado.

The American Journal of Tropical Medicine and Hygiene

|January 7, 2022

Summary

This summary is machine-generated.

A new COVID-19 serology control panel (CSCP) uses dried-tube specimens for easy shipping. This panel aids global laboratories in quality assurance and harmonizing COVID-19 antibody testing accuracy.

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Published on: April 6, 2021

Area of Science:

Clinical diagnostics and immunology
Virology and infectious diseases

Background:

Accurate serological testing for COVID-19 is crucial for disease surveillance and vaccine efficacy assessment.
Existing control materials often require cold chain logistics, limiting accessibility for global laboratories.

Purpose of the Study:

To develop and characterize a novel COVID-19 Serology Control Panel (CSCP) using dried-tube specimen (DTS) technology.
To ensure the CSCP provides reliable reactivity for various serological test platforms and aids in external quality assurance.

Main Methods:

Development of the CSCP utilizing the dried-tube specimen (DTS) procedure for sample preservation without cold chain requirements.
Characterization of immunoglobulin subtypes (total Ig, IgM, IgG) and their reactivity against SARS-CoV-2 antigens (nucleocapsid, spike, RBD).
Comparison of CSCP sample reactivity with the WHO International Standard to determine binding antibody units.

Main Results:

The DTS procedure enabled the creation of a stable serology control panel from convalescent COVID-19 samples collected between March-May 2020.
Detailed delineation of immunoglobulin subtype reactivity against key SARS-CoV-2 antigens was achieved.
Established binding antibody units for each sample, ensuring comparability across different serological test platforms.

Conclusions:

The developed CSCP, utilizing DTS, offers a stable, accessible, and standardized tool for global serological testing quality assurance.
The panel facilitates harmonization of laboratory testing and serves as valuable training material for laboratory personnel.
This innovation enhances the reliability and comparability of COVID-19 antibody testing worldwide.