Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

786
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
786
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

103
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
103

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-p200 Pemphigoid in an Infant Clinically Mimicking Linear IgA Disease.

Pediatric dermatology·2026
Same author

Diffuse Dermal Immunoglobulin Deposition and Monoclonal Gammopathy.

JAMA dermatology·2026
Same author

The role of antibody class and target on subepidermal blistering disease phenotype and management.

Italian journal of dermatology and venereology·2026
Same author

Durability of Conventional Immunosuppressants in the Treatment of Oral Lichen Planus.

The Journal of clinical and aesthetic dermatology·2026
Same author

The impact of allergen avoidance on oral lichen planus: A retrospective cohort-based comparison.

Journal of the American Academy of Dermatology·2025
Same author

An Allergy-Based Approach to Orofacial Granulomatosis: A Narrative Review.

Dermatitis : contact, atopic, occupational, drug·2025

Related Experiment Video

Updated: Oct 7, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

306

Diagnostics for Dermatologic Diseases with Autoantibodies.

Kristin M Leiferman1, Jeremy P Snook1, Mazdak A Khalighi1

  • 1Immunodermatology Laboratory, Department of Dermatology, University of Utah, UT, USA.

The Journal of Applied Laboratory Medicine
|January 7, 2022
PubMed
Summary

Autoantibodies targeting epithelial adhesion molecules cause blistering skin diseases. Autoantibody testing is crucial for diagnosing these autoimmune disorders, guiding treatment, and predicting prognosis.

Keywords:
basement membrane zone autoantibodiescell surface/intercellular substance antibodiescutaneous antibody indirect immunofluorescencecutaneous direct immunofluorescencedermatitis herpetiformisdesmosomal antigenshemidesmosomal antigensimmunobullous diseaselinear IgA diseasepemphigoidpemphigus

More Related Videos

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.7K
Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

36.3K

Related Experiment Videos

Last Updated: Oct 7, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

306
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.7K
Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

36.3K

Area of Science:

  • Immunodermatology
  • Autoimmunity
  • Diagnostic immunology

Background:

  • Autoimmune concepts have long recognized dermatologic diseases linked to autoantibodies.
  • Laboratory testing for autoantibodies in these conditions has advanced significantly.

Purpose of the Study:

  • To review clinical indications for autoantibody testing in dermatologic diseases.
  • To detail specimen collection, available diagnostic tests, and interpretation of results.
  • To discuss atypical presentations and future applications of autoantibody testing.

Main Methods:

  • Literature review of autoantibody testing in dermatologic diseases.
  • Analysis of clinical indications, specimen requirements, and diagnostic methodologies.
  • Exploration of atypical autoantibody profiles and future research directions.

Main Results:

  • Blistering dermatologic diseases involve autoantibodies targeting epithelial adhesion components, leading to skin separation.
  • Testing identifies disease-specific autoantibodies, aiding in diagnosis and management.
  • The review covers current testing, atypical findings, and future prospects.

Conclusions:

  • Autoantibody-associated dermatologic diseases significantly impact skin barrier function and patient well-being.
  • Accurate laboratory testing is essential for precise diagnosis, prognosis, and treatment decisions.
  • Understanding autoantibody profiles aids in recognizing associated systemic conditions.