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Updated: Oct 7, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
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Alleviation of Polycation-Induced Blood Coagulation by the Formation of Polypseudorotaxanes with Macrocyclic

Qiaoxian Huang1, Qian Cheng1, Xiangjun Zhang1

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China.

ACS Applied Bio Materials
|January 8, 2022
PubMed

Hexadimethrine bromide (HB), a polycation to neutralize heparin and control internal bleeding, may also cause serious blood coagulation that may be life-threatening. Reversal of HB by heparin and vice versa might potentially lead to a vicious circle of alternative bleeding and blood coagulation. In this Letter, a biocompatible synthetic nanoreceptor, cucurbit[7]uril (CB[7]), was demonstrated to dramatically alleviate HB-induced blood coagulation in vitro as well as in vivo, through the formation of HB@CB[7] polypseudorotaxanes. This discovery, for the first time, suggests the significant clinical potential of a synthetic receptor in alleviating the side effects and toxicity of a polycationic drug.

Keywords:
blood coagulationcucurbit[7]urilhexadimethrine bromidepolypseudorotaxanes

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