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Updated: Oct 7, 2025
Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
Published on: September 7, 2022
Morphology-Controllable Collagen/Poly(2-hydroxyethyl methacrylate) Porous Hydrogel with a Paraffin Microsphere as a
Keke Chen1, Xialian Fan1, Keyong Tang1
1School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
Abstract:
In this study, a porous poly(2-hydroxyethyl methacrylate) (PHEMA) matrix was fabricated by a paraffin template method, which was used as a substrate to adhere collagen fibers to form an interconnective porous collagen/PHEMA (Col-PHEMA) composite hydrogel. A microscope and scanning electron microscope (SEM) were employed to characterize the morphology of paraffin microspheres and Col-PHEMA composite hydrogels. The paraffin microspheres with the diameter in the range from 100 to 200 μm were collected by a preset sieve. Then, the interface of uniform paraffin microspheres were thermally bonded to form a contacted template, and the derived Col-PHEMA composite hydrogels had an interconnective porous microstructure. Fourier transform infrared spectroscopy (FTIR) indicated that new hydrogen bonds were formed between collagen fibers and the PHEMA hydrogel. Besides, the Col-PHEMA composite hydrogels revealed a high hydrophilicity, good mechanical properties, and good water uptake capacity. The porous Col-PHEMA composite hydrogels showed a good biocompatibility, and the collagen layer may promote the proliferation of fibroblast cells. The Col-PHEMA composite hydrogel is expected to find an application in corneal repairing.
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