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Updated: Oct 7, 2025
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Multilevel Nanoarchitecture Exhibiting Biosensing for Cancer Diagnostics by Dual-Modal Switching of Optical and
Ruichan Lv1,2, Miao Feng2, Liyang Xiao2
1Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, New York 14260, United States.
Abstract:
In this research, the fabrication and application of a multifunctional core-shell nanoarchitecture are proposed. NaYF4:Yb,Er@NaYF4:Yb,Nd exhibits upconversion luminescence (UCL) of erbium ions but has quenched UCL emission when it is coated with MnO2 nanosheets. This hierarchical multilevel UCNP-MnO2 exhibits restoration of UCL and generation of a magnetic resonance imaging (MRI) signal when it is exposed to a microenvironment containing glutathione (GSH)/H2O2, which strips the MnO2 sheets by converting them to paramagnetic Mn2+ ions. This dual-modal switching feature of the optical emission and MRI signals provides a platform for stimuli-responsive biosensing of GSH/H2O2. Our new formulation as a dual-modal biosensor for detecting aberrant levels of intracellular GSH/H2O2 associated in cancer cells could be a potential diagnostic probe to distinguish tumor cells from normal cells.
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