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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Light chain 3 immunoexpression in psoriasis.

Rehab M Samaka1, Alaa Marae2, Manar Faried2

  • 1Pathology Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.

Journal of Immunoassay & Immunochemistry
|January 8, 2022
PubMed
Summary
This summary is machine-generated.

Autophagy marker Light Chain 3 (LC3) is upregulated in psoriatic skin lesions. While LC3 may play a role in psoriasis pathogenesis, its levels did not correlate with disease severity in this study.

Keywords:
LC3Psoriasisautophagyimmunohistochemistryskin

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Area of Science:

  • Dermatology
  • Cell Biology
  • Molecular Biology

Background:

  • Autophagy dysregulation is implicated in various diseases.
  • The specific role of autophagy in psoriasis pathogenesis remains unclear.
  • Light Chain 3 (LC3) is a key marker for assessing autophagy activity.

Purpose of the Study:

  • To investigate the expression of LC3 in psoriatic skin.
  • To correlate LC3 expression with clinicopathological data in psoriasis patients.
  • To determine the potential role of LC3 in psoriasis pathogenesis.

Main Methods:

  • A prospective case-control study involving 60 subjects (30 controls, 30 psoriasis patients).
  • Immunohistochemical analysis of skin biopsies from control, lesional, and perilesional sites.
  • Assessment of LC3 immunoreaction and correlation with disease severity.

Main Results:

  • Significant upregulation of epidermal and dermal LC3 immunoreaction in lesional psoriatic skin compared to controls (P < .001).
  • A significant positive correlation was observed between epidermal and dermal LC3 H scores in lesional and perilesional skin.
  • No significant relationship was found between LC3 H scores in lesional skin and overall disease severity.

Conclusions:

  • LC3 upregulation suggests a potential role in psoriasis pathogenesis.
  • LC3 expression levels are not directly correlated with the clinical severity of psoriasis.
  • These findings may inform novel therapeutic strategies targeting autophagy in psoriasis.