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Updated: Oct 7, 2025

Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors
Published on: March 7, 2017
Gene of the month: NKX3.1
Jon Griffin1,2, Yuqing Chen3, James W F Catto4,5
1Histopathology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK jon.griffin@nhs.net.
Abstract:
NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.
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