Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

402
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
402
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

261
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
261
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

1.0K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
1.0K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

441
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
441
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

557
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
557
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

323
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
323

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fracture resistance of maxillary lateral incisors: effects of fiber post dimensions, material, and surface treatment.

BMC oral health·2026
Same author

Online food delivery services: cross-sectional study of consumers' attitude in Malaysia during and after the COVID-19 pandemic.

F1000Research·2026
Same author

Early versus Late starting of Direct Oral Anticoagulants after breakthrough ischemic stroke: A Target Trial Analysis from the ASPERA-R Study.

International journal of stroke : official journal of the International Stroke Society·2026
Same author

Synchronous ileo-ileal and ileocolic intussusception caused by an inverted giant Meckel's diverticulum in an adult: a rare case report.

International journal of surgery case reports·2026
Same author

Distinctive features of the tumor and immune microenvironment in glioblastoma.

NPJ precision oncology·2026
Same author

Mechanistic insight into complement C3 regulation during chronic HBV infection: effect on viral persistence and host immune response.

Journal of biomedical science·2026
Same journal

Who I am affects what I do.

Practical neurology·2026
Same journal

Recurrent falls while taking clozapine.

Practical neurology·2026
Same journal

Anti-Ma2 encephalitis: when the examination localises beyond MRI.

Practical neurology·2026
Same journal

Oculopharyngeal muscular dystrophy: diagnosis, management and multisystem care.

Practical neurology·2026
Same journal

Neurological signs of possible diagnostic value in the cognitive clinic: past, present and future.

Practical neurology·2026
Same journal

Longitudinally extensive myelitis in neurosarcoidosis.

Practical neurology·2026
See all related articles

Related Experiment Video

Updated: Oct 7, 2025

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.1K

Young-onset stroke complicating ulcerative colitis.

Su Yin Lim1, Mohamed Sayed2, Soma Banerjee2

  • 1Stroke and Neuroscience, Charing Cross Hospital, London, UK suyin.lim1@nhs.net.

Practical Neurology
|January 8, 2022
PubMed
Summary
This summary is machine-generated.

A teenage girl experienced multiple strokes during an ulcerative colitis flare-up, even after thrombectomy and anticoagulation. This case highlights the complex stroke risks and treatment challenges in inflammatory bowel disease.

Keywords:
MRIcerebral blood flowcerebrovascular diseasemedicinestroke

More Related Videos

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery
04:01

Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery

Published on: August 9, 2024

1.0K

Related Experiment Videos

Last Updated: Oct 7, 2025

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.1K
Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery
04:01

Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery

Published on: August 9, 2024

1.0K

Area of Science:

  • Neurology
  • Gastroenterology
  • Vascular Medicine

Background:

  • Inflammatory bowel disease (IBD), including ulcerative colitis, is associated with an increased risk of cerebrovascular events.
  • Cerebral artery occlusion is a rare but serious complication, particularly in younger patients.

Observation:

  • A 16-year-old female with acute ulcerative colitis presented with a right middle cerebral artery occlusion.
  • She underwent mechanical thrombectomy with successful recanalization, but experienced immediate reocclusion.
  • Subsequent ischemic events occurred despite therapeutic anticoagulation (heparin, low-molecular-weight heparin) and antiplatelet therapy (aspirin).

Findings:

  • Recurrent ischemic strokes occurred in a young patient with ulcerative colitis despite aggressive antithrombotic management.
  • The case underscores the thrombotic diathesis that can accompany severe inflammatory bowel disease flares.
  • Standard anticoagulation and antiplatelet strategies may be insufficient in managing arterial stroke in this population.

Implications:

  • Further research is needed to elucidate the mechanisms of stroke in IBD and optimize therapeutic strategies.
  • Clinicians should maintain a high index of suspicion for cerebrovascular events in IBD patients, especially during active inflammation.
  • Individualized treatment approaches considering the prothrombotic state in IBD may be necessary.