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Interrelationship between 2019-nCov receptor DPP4 and diabetes mellitus targets based on protein interaction network

Qian Gao1, Wenjun Zhang2, Tingting Li2

  • 1Affiliated Hospital of Shaoxing University of Endocrine and Metabolism Department, Zhejiang, China. 420293991@qq.com.

Scientific Reports
|January 8, 2022
PubMed

Insights

Patients with diabetes face higher COVID-19 risks. This study explores how Dipeptidyl peptidase-4 (DPP4), a coronavirus receptor, interacts with diabetes targets, suggesting DPP4 inhibitors and IL-6 antagonists may help manage severe cases.

Area of Science:

  • Biochemistry
  • Virology
  • Endocrinology

Background:

  • Diabetes mellitus patients exhibit increased susceptibility and mortality rates from Coronavirus disease 2019 (COVID-19).
  • Dipeptidyl peptidase-4 (DPP4) serves as a functional receptor for human coronaviruses, highlighting a potential link between diabetes and viral infection severity.

Purpose of the Study:

  • To investigate the intricate relationship between diabetes mellitus targets and DPP4.
  • To identify novel therapeutic strategies for managing patients with comorbid diabetes and COVID-19 through protein interaction network analysis.

Main Methods:

  • Collected diabetes mellitus targets from the GeneCards database, including DPP4.
  • Constructed and analyzed protein interaction networks using the String database.
  • Performed module identification, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.

Main Results:

  • Identified 43 DPP4-related proteins from diabetes targets, revealing three distinct functional modules.
  • Module 1 is associated with insulin secretion and the glucagon signaling pathway; Modules 2 and 3 are linked to signaling receptor binding.
  • LEP, apoB, INS, IL6, and ALB emerged as key proteins with high scores, indicating significant interactions within the network.

Conclusions:

  • Dipeptidyl peptidase-4 (DPP4) is extensively interconnected with critical proteins in diabetes mellitus.
  • COVID-19's impact on DPP4 in diabetic patients may contribute to elevated mortality.
  • DPP4 inhibitors and IL-6 antagonists represent potential therapeutic avenues to mitigate COVID-19's adverse effects in diabetic individuals.

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