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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
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Factors Affecting Drug Distribution: Tissue Permeability01:30

Factors Affecting Drug Distribution: Tissue Permeability

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The drug distribution process within the human body is a complex interplay of various physicochemical properties inherent to the drugs. These properties, including molecular size, ionization degree, partition coefficient, and stereochemical nature, significantly impact how drugs permeate biological membranes to reach their target tissues.
Small molecules with a molecular weight below 500 to 600 Daltons can easily pass through the capillary membrane, gaining access to different tissues. Larger...
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Related Experiment Video

Updated: Oct 7, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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How Does Fluid Flow Influence Drug Release from Drug Filled Implants?

David King1, Christopher McCormick2, Sean McGinty3,4

  • 1Division of Biomedical Engineering, University of Glasgow, Glasgow, UK.

Pharmaceutical Research
|January 8, 2022
PubMed
Summary

Fluid flow significantly impacts drug release from drug-filled implants (DFIs). Mathematical modeling shows orifice-based DFIs are sensitive to flow, unlike porous DFIs, guiding experimental design for accurate drug release quantification.

Keywords:
drug filled implantsdrug releasefluid dynamicsmathematical modellingporous implants

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Last Updated: Oct 7, 2025

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High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Mathematical Modeling

Background:

  • Drug-filled implants (DFIs) offer controlled drug delivery without carriers, potentially reducing inflammation and improving healing.
  • Standard in vitro drug release studies often involve stirring, but the effect of fluid flow on DFIs is not well understood.

Purpose of the Study:

  • To quantify the influence of fluid flow on drug release rates from two types of DFIs.
  • To compare the release behavior of porous DFIs versus orifice-based DFIs under fluid flow conditions.
  • To develop and validate mathematical models for predicting DFI drug release.

Main Methods:

  • Development of a multiphysics mathematical model simulating drug release from DFIs under induced fluid flow.
  • Comparison of drug release profiles from a porous pin DFI (μm pores) and an orifice pin DFI (mm orifices).
  • Application of 1D dissolution-diffusion and 3D dissolution-advection-diffusion models based on DFI design.

Main Results:

  • Fluid flow significantly alters drug release from orifice pin DFIs.
  • Porous pin DFIs exhibit drug release profiles largely insensitive to fluid flow.
  • Drug release is governed by the balance of reaction-advection-diffusion, indicated by nondimensional numbers.

Conclusions:

  • The design strategy of DFIs critically determines their sensitivity to fluid flow during in vitro release studies.
  • Simplified models suffice for porous DFIs, while complex models are needed for orifice DFIs under flow.
  • Findings impact the selection of appropriate experimental protocols for accurate DFI drug release characterization.