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Altered cortical activity in patients with lower limb amputation based on EEG microstate
Xinying Shan1,2, Conghui Wei3, Shaowen Liu3
1School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China.
Journal of Integrative Neuroscience
|January 8, 2022
Summary
Amputation alters electroencephalogram (EEG) microstates, specifically affecting microstate C duration and microstates B and D occurrence rates. This suggests EEG microstate analysis can reveal cortical function changes post-amputation.
Area of Science:
- Neuroscience
- Clinical Neurophysiology
Background:
- Electroencephalogram (EEG) microstates show alterations in various neuropsychiatric conditions.
- Investigating EEG microstates in individuals with amputation is crucial for understanding cortical adaptations.
Purpose of the Study:
- To explore resting-state EEG microstate differences between individuals with lower limb amputation and healthy controls.
- To determine if amputation impacts specific EEG microstate parameters.
Main Methods:
- Collected resting-state EEG data from 15 lower limb amputees and 20 healthy controls.
- Analyzed four classical EEG microstates (A-D) and their parameters: duration, occurrence rate, time coverage, and transition rate.
- Utilized statistical analysis to compare microstate parameters between groups.
Main Results:
- Significantly reduced duration of microstate C in the amputation group (p = 0.005).
- Significantly increased occurrence rates for microstate B (p = 0.03) and D (p = 0.002) in the amputation group.
- Significant differences in microstate transition rates (AC, CA, DB) were observed between groups.
Conclusions:
- Lower limb amputation leads to significant changes in resting-state EEG microstate characteristics.
- EEG microstate analysis serves as a potential method for investigating cortical functional alterations following amputation.
