Related Experiment Video
Updated: Oct 7, 2025

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review
Vojtech Brazdil1,2, Petr Kala3,4, Martin Hudec1,2
1Department of Internal Medicine and Cardiology, University Hospital Brno, Brno, Czech Republic.
Introduction:
Takotsubo syndrome (TTS), also known as stress cardiomyopathy or "broken heart" syndrome, is a mysterious condition that often mimics an acute myocardial infarction. Both are characterized by left ventricular systolic dysfunction. However, this dysfunction is reversible in the majority of TTS patients.
Purpose:
Recent studies surprisingly demonstrated that TTS, initially perceived as a benign condition, has a long-term prognosis akin to myocardial infarction. Therefore, the health consequences and societal impact of TTS are not trivial. The pathophysiological mechanisms of TTS are not yet completely understood. In the last decade, attention has been increasingly focused on the putative role of the central nervous system in the pathogenesis of TTS.
Conclusion:
In this review, we aim to summarize the state of the art in the field of the brain-heart axis, regional structural and functional brain abnormalities, and connectivity aberrancies in TTS.
Related Concept Videos
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's...
Pathophysiology of Heart Failure
Heart Failure II: Pathophysiology
Acute Coronary Syndrome III: Diagnostic Studies
Acute Coronary Syndrome I: Introduction

