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Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.

Cloé Domenighetti1, Pierre-Emmanuel Sugier1, Ashwin Ashok Kumar Sreelatha2

  • 1UVSQ, Univ. Paris-Sud, Inserm, Team "Exposome, Heredity, Cancer and Health," CESP, Université Paris-Saclay, Villejuif, France.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 8, 2022
PubMed
Summary

Higher dairy intake is linked to an increased risk of Parkinson's disease (PD), especially in men. This study used genetic data to confirm a causal relationship, independent of other factors.

Keywords:
dairy intake; Parkinson's disease; Mendelian randomization

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Area of Science:

  • Neuroscience and Genetics
  • Epidemiology

Background:

  • Prospective studies suggest dairy intake may increase Parkinson's disease (PD) risk, particularly in men.
  • The causal nature of this association, and potential confounding or reverse causation, remains unclear.

Purpose of the Study:

  • To investigate the causal association between genetically predicted dairy intake and Parkinson's disease risk.
  • Utilize two-sample Mendelian randomization (MR) to assess this relationship.

Main Methods:

  • Employed a well-established genetic instrumental variable for dairy intake (rs4988235) near the lactase gene.
  • Analyzed data from the Courage-PD consortium, including 9,823 PD patients and 8,376 controls of European ancestry.

Main Results:

  • A genetic predisposition for higher dairy intake was associated with an increased risk of PD (OR=1.70 per serving/day).
  • This association was significant in men (OR=2.50 per serving/day) but not in women, indicating a sex-specific effect.

Conclusions:

  • Mendelian randomization findings support a causal link between dairy consumption and elevated Parkinson's disease risk.
  • The observed association appears robust, not explained by confounding or reverse causation, though underlying mechanisms require further investigation.