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Related Experiment Video

Updated: Oct 7, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Sarcopenia in patients with multiple sclerosis.

Hatice Yuksel1, Mehtap Balaban2, Ozlem Ozturk Tan1

  • 1Department of Neurology, Ankara City Hospital, Ankara, Turkey.

Multiple Sclerosis and Related Disorders
|January 8, 2022
PubMed
Summary

Approximately one-fifth of multiple sclerosis (MS) patients exhibit sarcopenia, characterized by muscle loss. Sarcopenic MS patients experience higher fatigue and reduced physical activity compared to non-sarcopenic individuals.

Keywords:
Multiple sclerosisSarcopenia, fatigueSkeletal muscle massThigh muscle thickness

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Area of Science:

  • Neurology
  • Gerontology
  • Immunology

Background:

  • Multiple sclerosis (MS) is an autoimmune neurodegenerative disease affecting the central nervous system.
  • Sarcopenia, characterized by loss of muscle mass and function, is increasingly recognized for its impact on health outcomes.
  • The relationship between sarcopenia and MS remains under-investigated.

Purpose of the Study:

  • To determine the prevalence of sarcopenia in patients with multiple sclerosis.
  • To identify factors associated with sarcopenia in the MS population.

Main Methods:

  • Inclusion of 101 ambulatory MS patients and 55 healthy controls.
  • Assessment of handgrip strength (HGS), gait speed, anterior thigh muscle thickness (anterior TMT), and skeletal muscle mass index (SSMI) using ultrasound and bioelectrical impedance analysis (BIA).
  • Comparison of clinical data, fatigue (MFIS), and leisure-time exercise (GLTEQ) between sarcopenic and non-sarcopenic MS patients.

Main Results:

  • MS patients exhibited significantly lower HGS, gait speed, muscle mass, and thickness compared to controls.
  • Sarcopenia, particularly regional, was diagnosed in approximately one-fifth of MS patients.
  • Sarcopenic MS patients reported higher Modified Fatigue Impact Scale (MFIS) scores and lower Godin leisure-time exercise questionnaire (GLTEQ) scores.

Conclusions:

  • Regional sarcopenia is more prevalent than whole-body sarcopenia in MS patients.
  • Sarcopenia is associated with increased fatigue and reduced physical activity in individuals with MS.
  • These findings highlight the importance of assessing and managing sarcopenia in MS care.