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Related Concept Videos

Allergic Reactions

Allergic Reactions

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Cross-reactivity

Cross-reactivity

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Vaccinations

Vaccinations

Antibody Structure

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

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Related Experiment Video

Updated: Oct 7, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

[Anaphylaxis caused by vaccines].

Pablo Perea-Valle¹, Carlos Julio Delgado-Aguirre, Belkis Grindeli Villafuerte-Domínguez

¹Secretaría de Salud, Hospital Infantil de México Federico Gómez, Departamento de Alergia e Inmunología Clínica, Ciudad de México, México. pablopv28@gmail.com.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

|January 9, 2022

Summary

Anaphylaxis is a rare but serious allergic reaction to vaccines. Understanding its causes, including vaccine excipients, is crucial for safe vaccination practices and patient care.

Keywords:

Anaphylaxis Hypersensitivity Vaccination

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Last Updated: Oct 7, 2025

Measuring Local Anaphylaxis in Mice

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Published on: October 14, 2014

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Published on: June 29, 2021

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Published on: October 25, 2018

Area of Science:

Immunology
Vaccinology
Allergology

Background:

The SARS-CoV-2 pandemic accelerated vaccine development, but also fueled misinformation.
Anaphylaxis is a significant concern among vaccine adverse events.

Purpose of the Study:

To review anaphylaxis as a vaccine adverse event.
To discuss immunological mechanisms and diagnostic criteria for anaphylaxis.
To highlight the role of excipients in vaccine-associated anaphylaxis.

Main Methods:

Literature review on anaphylaxis and vaccine adverse events.
Analysis of immunological mechanisms and diagnostic criteria.
Examination of reported anaphylaxis rates for SARS-CoV-2 vaccines.

Main Results:

Anaphylaxis is a rare, life-threatening systemic allergic reaction.
Estimated anaphylaxis rates for SARS-CoV-2 vaccines range from 1:200,000 to 1:360,000 doses.
Excipients, not typically the active vaccine ingredient, are often implicated in reactions.

Conclusions:

Vaccine-associated anaphylaxis requires careful diagnosis and management by allergists.
Addressing concerns about anaphylaxis improves vaccine safety and public confidence.
Further research into vaccine components can enhance safety profiles.