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Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

Aristine Cheng¹, Steven M Holland²

¹Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md; Division of Infectious Diseases, Department of Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

The Journal of Allergy and Clinical Immunology

|January 9, 2022

Abstract:

Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.

Keywords:

Anticytokine autoantibodies adult-onset immunodeficiency anti-IFN-alpha anti–CM-CSF anti–IFN-γ anti–IL-12 anti–IL-17 anti–IL-23 chronic mucocutaneous candidiasis opportunistic infections protein alveolar proteinosis

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Keywords:

Anticytokine autoantibodies adult-onset immunodeficiency anti-IFN-alpha anti–CM-CSF anti–IFN-γ anti–IL-12 anti–IL-17 anti–IL-23 chronic mucocutaneous candidiasis opportunistic infections protein alveolar proteinosis

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